The Reds are looking for a first Premier League win since August and, on the back of a rousing comeback to defeat Roma in midweek, hopes are high that Old Trafford will be rocking again on Sunday.
Villa sit 10th in the table after three wins, three draws and three defeats and they were beaten 3-0 at Barcelona in the UEFA Champions League in midweek.
Back in March, the Reds overcame the Midlanders 3-1 at Old Trafford.
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Ross Barkley equalized after Casemiro’s opener, only for a beautiful through ball by Bruno Fernandes to release Matheus Cunha, who beat Emiliano Martinez to restore our lead.
Šeško came off the bench to wrap up the points for Carrick’s men.
Villa had a poor start to the season as Emery waited to bed his new signings in, following a summer of change at the Midlands club.
However, as was the case last term, they quickly found their feet and racked up six wins in seven games in all competitions.
The most recent of these was a 2-1 defeat of Manchester City, inflicting the Blues’ first domestic loss of the campaign.
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Since then, the Villans have exited the Carabao Cup to Bournemouth, drawn with Fulham and lost 3-0 at Barcelona in the Champions League.
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Carlos Baleba looks set to miss out after suffering a hamstring injury against Roma, although the full extent of the problem has not been confimed.
Former Villa star Youri Tielemans attracted praise from Michael Carrick for his performance after replacing his fellow summer signing.
Lisandro Martinez serves a one-game suspension for his red card in the defeat at Chelsea last weekend.
Luke Shaw, Manuel Ugarte, Marcus Rashford and Benjamin Šeško have been out of action but Patrick Chinazaekpere Dorgu has returned to training.
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Villa are without banned full-back Matty Cash but ex-Red Aaron Wan-Bissaka’s likely return could offset the Poland international’s absence.
Amadou Onana and Matteo Ruggeri could be the only other players unavailable for boss Unai Emery.
It’s an afternoon kickoff in the UK, which means a 11:30 a.m. kickoff on the East Coast of the U.S.
The match is on Sky Sports in the UK. Those Stateside can watch on USA. For Spanish language coverage, tune into Telemundo. In Canada, it’s on DAZN and Fubo.
Everyone else, head on over to LiveSoccerTV to find your viewing options.
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Manchester United predicted starting XI (4-2-3-1): Senne Lammens; Leny Yoro, Ayden Heaven, Harry Maguire, Diogo Dalot; Kobbie Mainoo, Youri Tielemans; Amad Diallo, Bruno Fernandes, Bryan Mbeumo; Matheus Cunha
Starting XI:
