Now they have six days to get ready for another road game with a growing injury list.
Starting right tackle Spencer Brown left Monday night’s 37-34 victory over the Los Angeles Rams because of a back injury and did not return, adding another starter to Buffalo’s list of health concerns.
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The Bills already played without wide receiver D.J. Moore, defensive tackle Ed Oliver, cornerback Dee Alford and wide receiver Joshua Palmer against the Rams.
Buffalo also had safety C.J. Gardner-Johnson, linebacker Terrel Bernard and cornerback Christian Benford leave briefly Monday, although all three returned.
The Las Vegas Raiders have their own injury questions entering Week 6, including running back Ashton Jeanty, who played through ankle and foot injuries in Sunday’s loss to New England.
Buffalo (4-1) visits Las Vegas (3-2) at 4:25 p.m. ET Sunday, Oct. 18, at Allegiant Stadium. The Bills have their bye in Week 7.
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NFL teams have to submit a report on practice participation on Wednesday, Thursday and Friday for a Sunday game. There are three levels of practice participation that can be designated: did not participate, limited participation and full participation.
A game status report is due by 4 p.m. Friday for Sunday games.
Here is the latest Bills vs. Raiders injury update for Week 6.
Spencer Brown is Buffalo’s biggest new injury concern entering Week 6.
Brown left Monday night’s game after Josh Allen completed a 6-yard pass to Khalil Shakir with 6:22 remaining in the second quarter.
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Bills athletic trainers tended to Brown on the field before he walked off under his own power. He appeared to grab at his back while walking toward the sideline and went directly into the blue medical tent. Brown later went to the locker room and did not return.
Buffalo initially listed Brown as questionable before downgrading him to out during the fourth quarter.
Bills coach Joe Brady did not have an update after the game.
Brown has dealt with back issues before. He underwent back surgery prior to the 2022 season and began 2025 training camp on the physically unable to perform list because of a back flare-up.
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Tylan Grable replaced Brown and played the final 48 offensive snaps at right tackle. He was flagged for offensive holding and a false start.
C.J. Gardner-Johnson gave Buffalo a scare Monday night.
Gardner-Johnson was injured while tackling Rams running back Blake Corum after a 34-yard catch-and-run late in the third quarter.
He stayed down after the play and repeatedly pointed toward his leg as Bills athletic trainers came onto the field. Gardner-Johnson eventually got up and limped off under his own power.
He returned for Buffalo’s next defensive possession and finished the game with seven tackles.
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Christian Benford returned Monday after missing Buffalo’s loss to New England in Week 4 because of a toe injury.
He left during the fourth quarter after tackling Puka Nacua and appeared to favor his right foot.
Benford returned later in the quarter and recorded 10 tackles in the win over the Rams.
Terrel Bernard left Monday night’s game during the fourth quarter after going down while attempting to tackle Rams running back Kyren Williams.
Ed Oliver missed Monday night’s game because of the knee injury he suffered against New England in Week 4.
Oliver did not practice at all last week.
The defensive tackle was injured during the third quarter against the Patriots when former Bills fullback Reggie Gilliam hit his left leg near the sideline.
Oliver also missed Buffalo’s Week 2 victory over Detroit because of a hip injury.
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Joshua Palmer was ruled out against the Rams after suffering a shoulder injury during Friday’s practice.
Palmer was not listed on Thursday’s injury report before being limited Friday and sitting out Saturday.
Bills coach Joe Brady said Saturday that Palmer got twisted up during practice.
Dee Alford missed Monday night’s game because of the ankle injury he suffered in Week 4.
He was listed as questionable but was inactive against the Rams.
Buffalo signed cornerback Anthony Kendall from the practice squad to the active roster before Monday’s game, giving the secondary additional depth.
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Landon Jackson #94 of the Buffalo Bills is checked on by medical staff during the third quarter against the New England Patriots at Highmark Stadium on October 04, 2026 in Orchard Park, New York.
Landon Jackson did not play against the Rams.
He suffered a knee injury in Week 4 but returned to the game in the loss to the Patriots.
Zane Durant is eligible to return after beginning the season on injured reserve.
Buffalo can designate Durant to return and open his 21-day practice window when he is medically cleared.
Tyrell Shavers is eligible to return after beginning the season on the physically unable to perform list.
Shavers is recovering from the torn ACL he suffered during Buffalo’s wild-card playoff victory last season.
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The Bills can designate him to return and open his 21-day practice window when he is ready.
Dorian Strong, CB, neck
Ashton Jeanty played against New England despite being listed as questionable because of ankle and foot injuries.
He rushed for 27 yards on 10 carries and caught five passes for 50 yards in the loss to the Patriots.
“Unless I can’t run, jump, I’m playing. Football is a tough game. You’re never gonna play feeling 100 percent,” Jeanty said. “So at the end of the day, I just want to go out there and do my best for my teammates and whatever it takes.”
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Tonka Hemingway left Sunday’s loss to New England during the first quarter with what the Raiders initially announced as a neck injury.
He was ruled out for the remainder of the game.
Raiders head coach Klint Kubiak said Monday that Hemingway entered the NFL concussion protocol.
Jalen Nailor missed Sunday’s loss to New England because of a concussion.
Raiders coach Klint Kubiak said Monday that Nailor is expected to return to practice this week as he works through the NFL concussion protocol.
Patrick Johnson left Sunday’s loss to New England during the second quarter with a neck injury.
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He did not return.
Trey Zuhn III missed Sunday’s game because of a knee injury.
Dont’e Thornton Jr. returned to practice last week while working his way back from injured reserve but was inactive in Week 5.